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Does High Protein Intake During First Week of Life Improve Growth and Neurodevelopmental Outcome at 18 months

Siddartha Buddhavarapu1, Saranya Manickaraj1, Abhay Lodha1

  • 1Section of Neonatology, Department of Pediatrics, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada.

Indian Journal of Pediatrics
|November 27, 2015
PubMed

Insights

High protein intake in the first week of life did not improve growth or neurodevelopmental outcomes for preterm infants. This study found no significant benefits at 18 months corrected age.

Area of Science:

  • Neonatal nutrition
  • Pediatric neurodevelopment
  • Preterm infant care

Background:

  • Early life nutrition is critical for preterm infant development.
  • Optimal protein intake in the neonatal period is debated.
  • Understanding the impact of early nutrition on long-term outcomes is essential.

Purpose of the Study:

  • To determine if increased protein intake in the first week of life affects growth and neurodevelopmental outcomes.
  • To evaluate outcomes at 18 months corrected age in extremely preterm infants.

Main Methods:

  • Retrospective cohort study comparing infants before and after a nutrition policy change.
  • Infants born before 29 weeks gestation were analyzed.
  • Growth and neurodevelopmental outcomes were assessed at 18 months corrected age.

Main Results:

  • No significant differences in growth or neurodevelopmental impairment rates were observed between groups.
  • High protein intake (>3.5 g/kg/d) was not associated with improved neurodevelopmental outcomes.
  • Gestational age and birth weight were similar between the pre- and post-intervention groups.

Conclusions:

  • High protein intake during the first week of life does not appear to enhance growth or neurodevelopmental outcomes in preterm infants.
  • Further research may be needed to establish optimal protein requirements.
  • Current findings suggest current protein intake strategies may not significantly alter long-term outcomes.
Abstract

Keywords:
GrowthNeonateNeurodevelopmental outcomesPretermProtein

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