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Trabecular bone score in kidney transplant recipients
K L Naylor1,2, L M Lix3, D Hans4
1Institute for Clinical Evaluative Sciences (ICES), London, ON, Canada.
Summary
Kidney transplant recipients show altered bone texture, with lower Trabecular Bone Score (TBS) linked to increased fracture risk. This bone texture measure offers insights beyond bone mineral density for assessing fracture in transplant patients.
Area of Science:
- Nephrology
- Orthopedics
- Radiology
Background:
- Trabecular Bone Score (TBS) is a texture analysis from DXA lumbar spine images, providing bone health information independent of bone mineral density (BMD).
- Assessing bone health in kidney transplant recipients is crucial due to potential complications affecting bone.
- This study investigates TBS characteristics and fracture risk in kidney transplant recipients.
Purpose of the Study:
- To evaluate bone texture using TBS in kidney transplant recipients.
- To determine the association between TBS and incident fractures in this population.
- To compare TBS between kidney transplant recipients and the general population.
Main Methods:
- Included 327 kidney transplant recipients and matched controls.
- Utilized lumbar spine DXA images to calculate TBS.
- Assessed non-traumatic fractures over a mean follow-up of 6.6 years using Cox proportional hazard regression.
Main Results:
- Kidney transplant recipients exhibited significantly lower lumbar spine TBS compared to controls.
- Lower TBS was independently associated with an increased risk of incident fractures.
- The association between lower TBS and fractures remained significant even after adjusting for BMD and FRAX score.
Conclusions:
- Kidney transplant recipients demonstrate abnormal bone texture as indicated by TBS.
- Lumbar spine TBS is a valuable tool for assessing fracture risk in kidney transplant recipients.
- TBS provides fracture prediction information independent of traditional BMD measurements.
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