Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

137
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
137
Non-Oral Extravascular Drug Absorption Routes01:15

Non-Oral Extravascular Drug Absorption Routes

657
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
657
Methods for Studying Drug Absorption: In situ01:09

Methods for Studying Drug Absorption: In situ

835
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
835
Ultrasonography01:17

Ultrasonography

8.4K
Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
8.4K
Drug Delivery: Overview01:16

Drug Delivery: Overview

1.1K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
1.1K
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

212
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
212

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial intelligence for skin permeability prediction: deep learning.

Journal of drug targeting·2024
Same author

Machine learning for skin permeability prediction: random forest and XG boost regression.

Journal of drug targeting·2023
Same author

Response to: Regarding the Article: Coronavirus Disease (COVID-19): Current Status and Prospects for Drug and Vaccine Development.

Archives of medical research·2021
Same author

COVID-19 Vaccines: New Developments and the Road Ahead.

Archives of medical research·2020
Same author

Coronavirus Disease (COVID-19): Current Status and Prospects for Drug and Vaccine Development.

Archives of medical research·2020
Same author

Polyplexes for gene and nucleic acid delivery: Progress and bottlenecks.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2020

Related Experiment Video

Updated: Mar 29, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
11:07

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Published on: November 24, 2021

3.4K

Recent progress in transdermal sonophoresis.

Kevin Ita1

  • 1a College of Pharmacy, Touro University , Vallejo , CA , USA.

Pharmaceutical Development and Technology
|November 27, 2015
PubMed
Summary
This summary is machine-generated.

Sonophoresis uses ultrasound to enhance transdermal drug delivery by overcoming the skin barrier. This review explores sonophoresis mechanisms, applications, and challenges for effective drug administration.

Keywords:
Acoustic streamingcavitationdrug deliverysonophoresistransdermal

More Related Videos

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells
07:16

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Published on: January 21, 2021

3.6K
Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System
09:07

Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System

Published on: February 10, 2023

3.4K

Related Experiment Videos

Last Updated: Mar 29, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
11:07

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Published on: November 24, 2021

3.4K
Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells
07:16

Assembly and Operation of an Acoustofluidic Device for Enhanced Delivery of Molecular Compounds to Cells

Published on: January 21, 2021

3.6K
Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System
09:07

Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System

Published on: February 10, 2023

3.4K

Area of Science:

  • Pharmacology
  • Biomedical Engineering
  • Drug Delivery Systems

Background:

  • Transdermal drug administration offers advantages but is limited by the stratum corneum's barrier function.
  • The stratum corneum presents a significant obstacle to effective topical and systemic drug delivery.
  • Overcoming the skin barrier is crucial for realizing the full therapeutic potential of transdermal routes.

Purpose of the Study:

  • To review the mechanisms of sonophoresis in facilitating transdermal drug delivery.
  • To discuss the applications and utilization of ultrasound in drug administration.
  • To highlight the challenges and toxicological aspects associated with sonophoresis.

Main Methods:

  • Literature review of sonophoresis mechanisms.
  • Analysis of studies on ultrasound-mediated transdermal drug delivery.
  • Examination of toxicological data related to sonophoresis.

Main Results:

  • Sonophoresis utilizes ultrasound to temporarily disrupt the stratum corneum, enhancing drug permeation.
  • Various mechanisms, including cavitation and thermal effects, contribute to increased transdermal transport.
  • Successful applications demonstrated for diverse therapeutic agents.

Conclusions:

  • Sonophoresis is a promising technique for improving transdermal drug delivery efficiency.
  • Understanding sonophoresis mechanisms and challenges is key to its clinical translation.
  • Further toxicological evaluation is necessary for safe and widespread application.