Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
Anorexia Nervosa01:28

Anorexia Nervosa

Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Bulimia Nervosa01:30

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
Binge Eating Disorders01:23

Binge Eating Disorders

Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ART in Europe, 2020: results generated from European registries by ESHRE†.

Human reproduction (Oxford, England)·2025
Same author

Cumulative live birth rates in a freeze-all or fresh transfer strategy after one ART cycle in ovulatory women.

Reproductive biomedicine online·2025
Same author

Survey on ART and IUI: legislation, regulation, funding, and registries in European countries-an update.

Human reproduction (Oxford, England)·2024
Same author

No major differences in perinatal and maternal outcomes between uninterrupted embryo culture in time-lapse system and conventional embryo culture.

Human reproduction (Oxford, England)·2023
Same author

Puberty disorders among ART-conceived singletons: a Nordic register study from the CoNARTaS group.

Human reproduction (Oxford, England)·2022
Same author

ART in Europe, 2018: results generated from European registries by ESHRE.

Human reproduction open·2022

Related Experiment Video

Updated: Jul 18, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

Dopamine and anorexia nervosa.

P Södersten1, C Bergh1, M Leon1

  • 1Karolinska Institutet, Section of Applied Neuroendocrinology, Mandometer Clinic, Huddinge, S-14104 Huddinge, Sweden.

Neuroscience and Biobehavioral Reviews
|November 27, 2015
PubMed
Summary

Reduced food intake may trigger anorexia nervosa by activating dopamine neurons, initially rewarding dieting. Addressing disordered eating, not just symptoms, improves outcomes in anorexia nervosa.

Keywords:
Anorexia nervosaAnorexia treatmentDopamineEating behaviorEating disordersEating pathologyMental consequences of food deprivation

More Related Videos

Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Related Experiment Videos

Last Updated: Jul 18, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
07:46

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa

Published on: October 22, 2015

Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Area of Science:

  • Neuroscience
  • Psychiatry
  • Behavioral Science

Background:

  • Reduced food intake may increase anorexia nervosa risk by engaging mesolimbic dopamine neurons, initially rewarding dieting.
  • fMRI studies confirm dopamine neuron activation in anorexia nervosa, but causality (disorder vs. nutritional deficit) is unclear.
  • Altered dopamine status in anorexia nervosa is hypothesized to stem from underlying brain abnormalities contributing to emotional disorder.

Purpose of the Study:

  • To investigate the role of mesolimbic dopamine neurons in anorexia nervosa.
  • To differentiate the effects of the disorder versus nutritional deficits on dopamine neuron activity.
  • To evaluate treatment strategies targeting symptoms versus disordered eating behavior.

Main Methods:

  • Review of existing literature on food intake, dopamine pathways, and anorexia nervosa.
  • Analysis of fMRI study findings related to dopamine neuron activation.
  • Comparative assessment of treatment outcomes based on theoretical perspectives.

Main Results:

  • Dopamine neuron activation is observed in anorexia nervosa, but its origin (disorder or malnutrition) remains debated.
  • Nutrient scarcity triggers a normal physiological foraging response involving dopamine neurons.
  • Treatments focusing on mental symptoms, consequences of food deprivation, show poor outcomes.

Conclusions:

  • Treatments targeting anorexia nervosa symptoms, which are consequences of food deprivation, yield poor results.
  • A therapeutic approach normalizing disordered eating behavior leads to superior physiological, behavioral, and emotional outcomes.
  • Understanding the interplay between nutrition, dopamine, and behavior is crucial for effective anorexia nervosa treatment.