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Updated: Mar 29, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
[Pathological and clinical correlations in renal AA amyloidosis: A Moroccan series of 30 cases]
Asmae Bziz1, Lamia Rouas1, Najat Lamalmi1
1Laboratoire d'anatomie cytologie pathologiques, faculté de médecine et de pharmacie, université Mohamed V, hôpital d'enfants, Rabat, Maroc.
Objective:
Study of histological and clinical correlations of 30 cases of renal amyloidosis AA diagnosed between November 2010 and December 2012.
Results:
The main causes associated with amyloidosis AA were represented by chronic infectious diseases (60%). Nephrotic syndrome and renal failure were observed in 94% and 73% respectively. The distribution of amyloid deposits: 90% of patients had a glomerular form and 10% had a vascular form. Inflammatory reaction associated with AA renal amyloidosis was present in 50% of cases. This inflammation was observed near amyloid deposits associated with a deposition of immunoglobulin chains and/or complement factors.
Conclusion:
Our study confirms the predominance of AA amyloidosis complicating chronic infectious diseases, especially tuberculosis. Our data point out a relationship between the morphology of renal AA amyloidosis, its clinical presentation and prognosis.
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