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PTH modulation of NCC activity regulates TRPV5 Ca2+ reabsorption

Robert S Hoover1, Viktor Tomilin2, Lauren Hanson3

  • 1Division of Nephrology, Department of Medicine, Emory University, Atlanta, Georgia; Atlanta Veteran's Administration Medical Center, Decatur, Georgia;

American Journal of Physiology. Renal Physiology
|November 27, 2015
PubMed
Summary

Parathyroid hormone (PTH) enhances calcium reabsorption by increasing TRPV5 activity and decreasing NCC activity. This study shows that modulating NCC activity is crucial for PTH

Keywords:
parathyroid hormonesodium-chloride cotransporterthiazidetransient receptor potential vanilloid 5 channelwith no lysine kinase

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