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Updated: Mar 29, 2026

Accessing the Cytotoxicity and Cell Response to Biomaterials
Published on: July 8, 2021
[Zinc signaling-mediated regulation of dentin and periodontal tissues]
Toshiyuki Fukada1, Yayoi Idaira2, Shinji Shimoda3
1Tokushima Bunri University, Faculty of Pharmaceutical Sciences, Molecular and Cellular Physiology, Japan.
Abstract:
An essential trace element zinc is required for variety of cellular functions and physiological responses, therefore, downregulation of zinc homeostasis cause serious problems in health, such as growth retardation and abnormal bone formation. Recent technical advances contributed to reveal that zinc ion regulated by zinc transporters acts as a signaling mediator, called zinc signaling that involves in mammalian physiology and pathogenesis. This review will address the current understanding of the roles of zinc signaling in regulation of dentin formation and periodontal tissues homeostasis.
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