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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Related Experiment Video

Updated: Mar 29, 2026

SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
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SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

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VEGF involvement in psoriasis.

Mihaela Elena Marina1, Iulia Ioana Roman2, Anne-Marie Constantin1

  • 1Department of Histology and Morphological Sciences, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Clujul Medical (1957)
|November 27, 2015
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Summary

Vascular endothelial growth factor (VEGF) and its receptors (VEGFR) are implicated in psoriasis development. Targeting the VEGF pathway shows promise for new psoriasis treatments by inhibiting excessive skin vascularity.

Keywords:
VEGFVEGFRpsoriasis

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A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
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Area of Science:

  • Molecular Biology
  • Dermatology
  • Pathophysiology

Background:

  • Vascular endothelial growth factor (VEGF) is crucial for neovascularization in development and disease.
  • VEGF receptors (VEGFR) are expressed on various cell types, including endothelial cells.
  • Psoriasis is characterized by increased dermal vascularity and VEGF production.

Purpose of the Study:

  • To investigate the role of VEGF/VEGFR signaling in psoriasis pathogenesis.
  • To evaluate the potential of targeting the VEGF pathway for psoriasis treatment.

Main Methods:

  • The study focuses on the molecular mechanisms of VEGF/VEGFR signaling in psoriasis.
  • It reviews current therapeutic strategies targeting the VEGF pathway.

Main Results:

  • Excessive VEGF production and dermal vascularity are key markers of psoriasis.
  • VEGF/VEGFR signaling plays a pathological role in psoriasis onset and progression.

Conclusions:

  • The VEGF/VEGFR pathway is a significant therapeutic target for psoriasis.
  • Targeted therapies, including antibodies, are being developed to treat psoriasis by modulating this pathway.