Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

99
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
99
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

32
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
32
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

62
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
62
Viral Meningitis01:18

Viral Meningitis

84
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
84
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.5K
Atypical Pneumonia01:14

Atypical Pneumonia

38
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
38

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Dance of Wuchereria bancrofti on Ultrasound.

Indian journal of pediatricsยท2026
Same author

Pediatric acute liver failure in a child with arsenic toxicity and underlying rotor syndrome.

Oxford medical case reportsยท2026
Same author

Intestinal failure-associated liver disease in a child with short bowel syndrome: management issues.

Oxford medical case reportsยท2026
Same author

Esophageal Stricture in a 5-Year-Old Child with Epidermolysis Bullosa: Case Report of a Rare Complication at a Very Young Age.

Case reports in gastroenterologyยท2026
Same author

Antibiotic Prophylaxis Optimization Using Fecal Surveillance Culture in Operated Biliary Atresia Patients: A Retrospective Study on Cholangitis Prevention.

Journal of Indian Association of Pediatric Surgeonsยท2026
Same author

Celiac disease presenting As recurrent encephalopathy and seizures.

Oxford medical case reportsยท2026

Related Experiment Video

Updated: Mar 29, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

25.3K

Methicillin resistant Staphylococcus aureus meningitis.

Noella Maria Delia Pereira1, Ira Shah1, Alpana Ohri1

  • 1Department of Pediatrics , Bai Jerbai Wadia Hospital for Children , Parel, Mumbai , India.

Oxford Medical Case Reports
|November 27, 2015
PubMed
Summary

Methicillin-resistant Staphylococcus aureus (MRSA) meningitis is a rare but serious infection in children. This case highlights a successful treatment of MRSA meningitis with a combination antibiotic regimen in an 11-year-old girl.

More Related Videos

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.8K
Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat

Published on: June 4, 2012

18.1K

Related Experiment Videos

Last Updated: Mar 29, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

25.3K
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.8K
Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat

Published on: June 4, 2012

18.1K

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neurology

Background:

  • Meningitis caused by Methicillin-resistant Staphylococcus aureus (MRSA) is uncommon in pediatric populations.
  • Early diagnosis and appropriate treatment are crucial for managing severe infections.

Observation:

  • An 11-year-old girl presented with symptoms including fever, headache, vomiting, right hemiparesis, left facial nerve palsy, and bladder incontinence.
  • Neurological examination revealed signs consistent with meningitis and a focal neurological deficit.

Findings:

  • Diagnostic investigations confirmed MRSA meningitis.
  • Cerebral imaging identified an acute left thalamo-corpuscular infarct.
  • The patient was treated with a combination of vancomycin, linezolid, and rifampicin.

Implications:

  • This case underscores the possibility of MRSA meningitis in children, despite its rarity.
  • Successful treatment with a multi-drug regimen suggests effective therapeutic options are available.
  • Prompt management can lead to favorable outcomes, although residual neurological deficits may persist.