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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

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Published on: February 19, 2016

Solid lipid nanoparticles from amphiphilic calixpyrroles.

Kaisa Helttunen¹, Albano Galán², Pablo Ballester³

¹University of Jyvaskyla, Department of Chemistry, Nanoscience Center, P.O. Box 35, FI-40014 University of Jyvaskyla, Finland.

Journal of Colloid and Interface Science

|November 27, 2015

Summary

Aryl-extended calixpyrroles form stable, small solid lipid nanoparticles (SLNs) with potential for drug encapsulation. Meso-dodecyl calixpyrroles yield optimal SLN size and stability, influenced by preparation conditions.

Keywords:

Amphiphile Calixpyrrole Dynamic light scattering Macrocycle Nanoparticle tracking analysis Solid lipid nanoparticle Zeta potential

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Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

Area of Science:

Supramolecular chemistry
Materials science
Nanotechnology

Background:

Macrocyclic amphiphiles self-assemble into structures like solid lipid nanoparticles (SLNs), useful for drug encapsulation.
Aryl-extended calixpyrroles, known anion hosts, are investigated for SLN formation despite unusual alkyl chain geometry.
Preparation conditions and alkyl chain length are hypothesized to influence SLN size and stability.

Purpose of the Study:

To investigate the formation and characteristics of SLNs from aryl-extended calixpyrroles.
To compare SLNs derived from calixpyrroles with different alkyl chain lengths (meso-dodecyl vs. meso-methyl).
To determine the impact of preparation parameters (solvent ratios, pH, salt concentration) on SLN properties.

Main Methods:

Synthesis and characterization of SLNs from two aryl-extended calixpyrroles (meso-dodecyl and meso-methyl).
Dynamic light scattering and nanoparticle tracking analysis to assess particle size and distribution.
Zeta potential measurements to evaluate surface charge under varying pH and NaCl concentrations.

Main Results:

Meso-dodecyl calixpyrrole produced stable SLNs (40-70nm) in 0.86-4.28M ethanol.
Meso-methyl calixpyrrole resulted in larger, less stable SLNs.
Optimal particle size was achieved at low calixpyrrole concentration and specific ethanol/water ratios.
Increased pH enhanced particle stability due to a more negative surface charge.

Conclusions:

Aryl-extended calixpyrroles can form stable SLNs, with meso-dodecyl variants showing superior characteristics.
Particle size and stability are tunable via calixpyrrole structure and preparation conditions.
These findings support the potential of calixpyrrole-based SLNs for applications like drug delivery.