Related Experiment Video
Updated: Mar 29, 2026

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
Published on: December 1, 2023
A numerical solution of the mechanical bidomain model
Samip Gandhi1, Bradley J Roth1
1a Department of Physics , Oakland University , Rochester , MI , USA.
Introduction:
The mechanical bidomain model predicts forces on integrin proteins in the membrane. It has been solved analytically for idealized examples, but a numerical algorithm is needed to address realistic problems.
Methods:
The bidomain equations are approximated using finite differences. An ischemic region is modeled as a circular area having no active tension, surrounded by normal tissue.
Results:
The membrane force is large in the ischemic border zone, but is small elsewhere. Strain is distributed widely throughout the ischemic region and surrounding tissue.
Conclusion:
This calculation provides a testable prediction for the mechanism of mechanotransduction and remodeling in cardiac tissue.
Related Concept Videos
Typical Model Studies
Design Example: Creating a Hydraulic Model of a Dam Spillway
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
The Buckingham Pi Theorem
Major Losses in Pipes
Fluid flow can be classified as laminar or turbulent, primarily based on the Reynolds number. This dimensionless number reflects the relative influence of inertial to viscous...
Modeling and Similitude

