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Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi
Wan-Fei Li1, Juan Wang2,3, Jing-Jie Zhang4
1Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China. wanfeier@live.cn.
International Journal of Molecular Sciences
|November 28, 2015
Abstract:
Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).