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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Kidney Transplant III: Nursing Management01:16

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Related Experiment Video

Updated: Mar 29, 2026

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
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One hundred ABO-incompatible kidney transplantations between 2004 and 2014: a single-centre experience.

Stefan Zschiedrich1, Bernd Jänigen2, Dilyana Dimova1

  • 1Renal Division, Department of Medicine, University Medical Centre Freiburg, Freiburg, Germany.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|November 28, 2015
PubMed
Summary

ABO-incompatible kidney transplants (ABOi KTx) show excellent long-term survival rates, comparable to ABO-compatible transplants (ABOc KTx). This study confirms ABOi KTx is a safe and effective option to increase kidney transplant availability.

Keywords:
ABO-incompatible kidney transplantationcomplicationshigh-titre isohaemagglutinin patientslong-term outcomerejections

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Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Surgical Outcomes

Background:

  • ABO-incompatible kidney transplantation (ABOi KTx) broadens living donor options.
  • Limited long-term outcome data comparing ABOi KTx with ABO-compatible kidney transplantation (ABOc KTx).

Purpose of the Study:

  • To compare the long-term outcomes of ABOi KTx with ABOc KTx.
  • To evaluate patient and graft survival, rejection rates, and complications in ABOi KTx.

Main Methods:

  • Observational, single-centre study analyzing 100 ABOi KTx and 248 ABOc KTx recipients.
  • Follow-up period of up to 10 years for ABOi KTx patients.
  • Exclusion of patients on cyclosporine A-based immunosuppression.

Main Results:

  • Median 10-year patient survival: 99% for ABOi KTx vs. 80% for ABOc KTx.
  • Median 10-year graft survival: 94% for ABOi KTx vs. 88% for ABOc KTx.
  • Similar rates of antibody-mediated and T-cell-mediated rejections; no increased infectious or malignant complications, but more lymphoceles in ABOi KTx.

Conclusions:

  • Long-term outcomes of ABOi KTx are not inferior to ABOc KTx.
  • ABOi KTx is a safe and successful option to address organ shortages.
  • Vigorous immunosuppression in ABOi KTx does not increase rejection, infection, or malignancy rates.