Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid differentiation
Sujit Kootala1, Yu Zhang1, Sara Ghalib1
1Science for Life Laboratory, Department of Chemistry-Ångström Laboratory, Uppsala University, Uppsala, Sweden. dmitri.ossipov@kemi.uu.se.
Biomaterials Science
|November 28, 2015
Abstract:
An in situ cross-linkable hyaluronan hydrogel functionalized with bisphosphonate (BP) groups allows tunable release of bone morphogenetic protein-2 (BMP-2) determined by the amount of BP groups. The high affinity of matrix-anchored BP groups towards BMP-2 permits guided differentiation of entrapped progenitor cells in 3-D cultures.
