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Liver Function Assessment Using Parenchyma-Specific Contrast-Enhanced Ultrasonography.

Jaehyung Park1, Jinhan Cho1, Heejin Kwon1

  • 1Department of Radiology, Dong-A University College of Medicine, Busan, Republic of Korea.

Ultrasound in Medicine & Biology
|November 28, 2015
PubMed
Summary

Contrast-enhanced ultrasonography (CEUS) can assess liver function in cirrhosis patients. The time from peak to one half of the enhancement curve effectively predicts hepatic reserve, correlating with indocyanine green tests.

Keywords:
Contrast-enhanced ultrasonographyIndocyanine greenLiver cirrhosisLiver functionMicrobubble contrast agentSonazoid

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Area of Science:

  • Hepatology
  • Diagnostic Imaging
  • Medical Ultrasound

Background:

  • Assessing hepatic functional reserve is crucial for managing liver cirrhosis.
  • Traditional methods like indocyanine green (ICG) tests have limitations.
  • Parenchyma-specific contrast-enhanced ultrasonography (CEUS) offers a non-invasive imaging approach.

Purpose of the Study:

  • To evaluate the utility of CEUS-derived hepatic parenchyma enhancement curves for assessing liver functional reserve.
  • To correlate hemodynamic parameters from CEUS time-intensity curves with indocyanine green retention rate at 15 minutes (ICG R15).

Main Methods:

  • Fifty-two patients with liver cirrhosis and focal liver lesions were enrolled.
  • CEUS was performed, and time-intensity curve parameters were analyzed.
  • Comparison was made between CEUS parameters and ICG R15 values.

Main Results:

  • A statistically significant correlation was found between the time from peak to one half (s) and ICG R15.
  • The time from peak to one half showed a proportional relationship with ICG R15.
  • A cut-off value of 149 s for time from peak to one half demonstrated high sensitivity (85.7%) and specificity (92.3%) for detecting abnormal ICG R15 (>14).

Conclusions:

  • The time from peak to one half parameter derived from parenchyma-specific CEUS is a valuable tool for predicting hepatic reserve in liver cirrhosis.
  • CEUS offers a promising alternative or complementary method to ICG testing for liver function assessment.