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Multiple sclerosis and infections

Arun Venkatesan1

  • 1Division of Neuroimmunology & Neuroinfectious Diseases, Johns Hopkins Hospital, 600 North Wolfe Street, Meyer 6-113, Baltimore, MD 21287, USA.

Neurodegenerative Disease Management
|November 28, 2015
PubMed

Insights

Infections and multiple sclerosis (MS) have a complex, two-way relationship. This review examines how infections impact MS development and complications throughout a patient's life.

Area of Science:

  • Neuroimmunology
  • Infectious Diseases
  • Microbiome Research

Background:

  • The relationship between infections and multiple sclerosis (MS) is intricate and bidirectional.
  • Infectious agents are investigated for their potential role in MS initiation.
  • The gut microbiome's influence on established MS is an emerging area of research.

Purpose of the Study:

  • To review the complex interplay between infections and multiple sclerosis (MS).
  • To examine the clinical manifestations and epidemiology of infections in MS patients.
  • To discuss data from both animal models and human studies.

Main Methods:

  • Literature review of existing studies.
  • Analysis of data from animal models.
  • Examination of human clinical data.

Main Results:

  • Infections are implicated in MS initiation.
  • The gut microbiome may influence established MS.
  • Systemic and CNS infections are significant MS complications.

Conclusions:

  • The bidirectional link between infections and MS requires further investigation.
  • Understanding infection epidemiology in MS is crucial for patient management.
  • Future research should explore therapeutic strategies targeting these interactions.
Keywords:
infectionsmultiple sclerosisreview

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