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[Aortic inflammatory lesions in Behçet's disease].
A-C Desbois1, B Wechsler1, P Cacoub1
1Service de médecine interne et d'immunologie clinique, Centre national de référence des maladies auto-immunes et systémiques rares, université Pierre-et-Marie-Curie, DHU i2B, inflammation, immunopathologie, biothérapie, groupe hospitalier Pitié-Salpêtrière, Assistance publique-Hôpitaux de Paris (AP-HP), Paris 6, 83, boulevard de l'Hôpital, 75013 Paris, France.
La Revue De Medecine Interne
|November 28, 2015
Summary
Behçet
Area of Science:
- Vascular Medicine
- Rheumatology
- Immunology
Background:
- Behçet's disease (BD) involves arterial lesions in approximately 10% of patients.
- Aortic aneurysms are the predominant arterial manifestation, often affecting the abdominal aorta and contributing to disease severity and mortality.
Purpose of the Study:
- To provide a comprehensive and updated review of aortic inflammatory damage in Behçet's disease.
- To detail the clinical presentation, histopathology, and management strategies for aortic involvement in BD.
Main Methods:
- Literature review of studies on aortic lesions in Behçet's disease.
- Analysis of clinical, imaging, and histopathological findings.
- Review of current therapeutic approaches.
Main Results:
- Aortic involvement, particularly aneurysms, is a common and severe arterial manifestation in BD.
- Histopathology reveals inflammatory cell infiltration and vascular proliferation.
- Symptoms can range from asymptomatic to severe pain and aortic insufficiency.
Conclusions:
- Aortic lesions in Behçet's disease require a multidisciplinary approach.
- Management involves controlling inflammation with medical therapy and addressing aneurysms with endovascular or surgical interventions.
- Early diagnosis and tailored treatment are crucial for improving outcomes.
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