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Updated: Mar 29, 2026
Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images
Published on: May 23, 2019
MRI-Guided Delivery of Viral Vectors
Ernesto A Salegio1,2, John Bringas1, Krystof S Bankiewicz3
1Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, 94103-0555, USA.
Abstract:
Gene therapy has emerged as a potential avenue of treatment for many neurological disorders. Technological advances in imaging techniques allow for the monitoring of real-time infusions into the brain of rodents, nonhuman primates, and humans. Here, we discuss the use of magnetic resonance imaging (MRI) as a tool in the delivery of adeno-associated viral (AAV) particles into brain of nonhuman primates.
