Related Experiment Video
Updated: Mar 29, 2026

Lumbar Intrathecal Injection of Gene Therapy Vectors for Central Nervous System Targeting in Mice and Rats
Published on: May 16, 2025
Systemic Gene Therapy for Targeting the CNS
Sara E Gombash1,2, Kevin D Foust3
1Department of Translational Science& Molecular Medicine, Michigan State University, Grand Rapids, MI, USA.
Abstract:
Systemic gene delivery is useful for modeling and treatment of a body-wide disease. Recently, it has been shown that certain agents, when delivered systemically, can efficiently target the central nervous system. This technique has been used to model and treat rodent models of neurological disease with unprecedented success. Here, we describe intravenous delivery in neonate and adult mice. These techniques are easily learned and have minimal equipment requirements.
Related Concept Videos
Gene Therapy
Gene Therapy

