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Gene Therapy-Based Modeling of Neurodegenerative Disorders: Huntington's Disease
1Department of Pharmacology & Clinical Pharmacology & Centre for Brain Research, School of Medical Sciences, University of Auckland, Auckland, New Zealand. ds.young@auckland.ac.nz.
Abstract:
Huntington's disease is a fatal neurodegenerative disease characterized by impairments in motor control, and cognitive and psychiatric disturbances. In this chapter, viral vector-mediated approaches used in modeling the key neuropathological features of the disease including the production of abnormal intracellular protein aggregates, neuronal dysfunction and degeneration and motor impairments in rodents are described.
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