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Vitamin B6 requirements and recommendations.

D A Bender1

  • 1Department of Biochemistry, University College, London, UK.

European Journal of Clinical Nutrition
|May 1, 1989
PubMed
Summary

Vitamin B6 is crucial for amino acid metabolism and hormone function. While average intakes meet recommendations, 10-25% show biochemical deficiency, with no clear clinical significance or safe higher intake levels.

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Area of Science:

  • Biochemistry
  • Human Nutrition
  • Metabolism

Background:

  • Vitamin B6 is essential for amino acid metabolism and steroid hormone function.
  • Body stores are primarily in muscle, linked to glycogen phosphorylase.
  • Requirements are typically calculated based on protein intake.

Purpose of the Study:

  • To review vitamin B6 requirements and nutritional status.
  • To assess recommended daily allowances (RDAs) and safe intake levels.
  • To evaluate the clinical significance of biochemical deficiencies and risks of high intake.

Main Methods:

  • Analysis of existing data on vitamin B6 requirements and intake.
  • Comparison of RDAs from different authorities.
  • Review of biochemical evidence for nutritional status.
  • Assessment of safety data for high vitamin B6 doses.

Main Results:

  • Adequate intake is generally set at 15 micrograms/g dietary protein; RDAs range from 1.5-2.2 mg/d.
  • A minimum safe intake is 11 micrograms/g dietary protein.
  • 10-25% of populations in developed countries show biochemical evidence of inadequate vitamin B6 status.
  • High intakes (50-500+ mg/d) carry risks of neurological damage.

Conclusions:

  • Average vitamin B6 intake meets targets, but biochemical deficiencies persist in a significant portion of the population.
  • The clinical significance of this biochemical deficiency is unknown.
  • High-dose vitamin B6 supplementation is not recommended due to potential hazards.

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