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A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

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Morphologic Updates in Prostate Pathology.

Adebowale J Adeniran¹, Peter A Humphrey¹

¹Department of Pathology, Yale University School of Medicine, 310 Cedar Street, LH 108, New Haven, CT 06520, USA.

Surgical Pathology Clinics

|November 28, 2015

Summary

Recent updates to the Gleason grading system and the discovery of new prostate cancer variants impact treatment and prognosis. Immunohistochemistry aids in accurate prostate pathology diagnosis.

Keywords:

Active surveillance Gleason system Immunohistochemistry Prostatic adenocarcinoma

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Published on: May 11, 2016

Area of Science:

Urology
Pathology
Oncology

Background:

The Gleason grading system for prostate cancer has undergone modifications.
Morphologic variants of prostatic adenocarcinoma have been identified.
Advances in immunohistochemistry have improved prostate pathology diagnostics.

Purpose of the Study:

To provide an update on prostate pathology.
To discuss the evolution of the Gleason grading system.
To highlight the role of immunohistochemistry in diagnosing prostate cancer.

Main Methods:

Review of recent modifications to the Gleason grading system.
Description of morphologic variants of prostatic adenocarcinoma.
Discussion of the application of immunohistochemical stains in prostate pathology.

Main Results:

Modified Gleason grading systems have therapeutic and prognostic implications.
Several morphologic variants of prostatic adenocarcinoma are recognized.
Immunohistochemistry is a valuable tool in prostate pathology.

Conclusions:

The Gleason grading system continues to evolve, impacting patient management.
Understanding prostatic adenocarcinoma variants is crucial for accurate diagnosis.
Immunohistochemistry enhances the diagnostic capabilities in prostate pathology.