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Metabolic exit from naive pluripotency.

Jun Wu1, Juan Carlos Izpisua Belmonte1

  • 1Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, California 92037, USA.

Nature Cell Biology
|November 28, 2015
PubMed
Summary

Researchers discovered how the metabolome and histone modifications drive the metabolic switch from naive to primed pluripotency in early human development. This finding offers new insights into modeling embryogenesis in vitro.

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