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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Non-LTR Retrotransposons03:18

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Long noncoding RNAs in hematopoietic malignancies.

Norma I Rodríguez-Malavé1, Dinesh S Rao2

  • 1Cellular and Molecular Pathology Program, Department of Pathology and Laboratory Medicine, University of California Los Angeles, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, University of California Los Angeles Cellular and Molecular Pathology Program, Department of Pathology and Laboratory Medicine, University of California Los Angeles, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, University of California Los Angeles.

Briefings in Functional Genomics
|November 28, 2015
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are crucial for cellular processes and gene regulation. This review highlights the role of lncRNAs in the development and pathogenesis of blood cancers.

Keywords:
ALLAMLCMLMDSMPNlncRNA

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Noncoding RNAs (ncRNAs) regulate cellular processes, including gene expression.
  • Long noncoding RNAs (lncRNAs) are a recently identified class of ncRNAs with diverse regulatory functions.
  • LncRNA dysregulation is implicated in various diseases, including hematopoietic malignancies.

Purpose of the Study:

  • To review the role of lncRNAs in hematopoietic development.
  • To focus on lncRNAs involved in the pathogenesis of hematopoietic malignancies.

Main Methods:

  • Literature review of recent studies on lncRNAs and hematopoietic malignancies.
  • Analysis of lncRNA functions in gene expression, chromatin remodeling, and other cellular processes.

Main Results:

  • LncRNAs play critical roles in normal hematopoietic development.
  • Specific lncRNAs are dysregulated in hematopoietic malignancies, contributing to their pathogenesis.
  • LncRNAs are involved in key cellular functions relevant to cancer development, such as transcriptional regulation and splicing.

Conclusions:

  • LncRNAs are essential regulators in hematopoiesis.
  • Understanding lncRNA involvement in hematopoietic malignancies offers potential therapeutic targets.
  • Further research into lncRNA function is crucial for advancing cancer biology and treatment.