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Related Concept Videos

Mutations01:35

Mutations

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Hypersensitivity Reactions: Immune-Complex Reactions01:19

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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Pigmentation01:19

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Hypersensitivity Reactions: Cytolytic Reactions01:01

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Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
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Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
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Solar urticaria.

Steven Goetze1, Peter Elsner1

  • 1Department of Dermatology, University Medical Center Jena, Jena, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|November 28, 2015
PubMed
Summary
This summary is machine-generated.

Solar urticaria is a rare skin condition triggered by sunlight. Diagnosis involves identifying the action spectrum and minimal urticarial dose, with treatments ranging from antihistamines to newer therapies for severe cases.

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Area of Science:

  • Immunodermatology
  • Photobiology
  • Allergy and Immunology

Background:

  • Solar urticaria is a rare, IgE-mediated photodermatosis.
  • Chromophores, termed
  • serum factor
  • may be present in patient serum.
  • The precise pathogenesis of solar urticaria remains unclear.

Purpose of the Study:

  • To review the clinical features, diagnosis, and management of solar urticaria.
  • To highlight the importance of determining the action spectrum and MDU.
  • To discuss differential diagnoses and emerging treatments.

Main Methods:

  • Clinical case review and literature synthesis.
  • Diagnostic criteria and therapeutic approaches for solar urticaria.
  • Analysis of triggers (UVA, visible light) and differential diagnoses (polymorphic light eruption, porphyrias).

Main Results:

  • Urticarial lesions appear rapidly after light exposure, suggesting solar urticaria.
  • Action spectrum determination and MDU are critical for diagnosis.
  • Sunlight avoidance, antihistamines, and light hardening are primary treatments.

Conclusions:

  • Solar urticaria requires prompt diagnosis through specific testing.
  • Management involves trigger avoidance and symptomatic treatment.
  • Advanced therapies like plasmapheresis and omalizumab are options for refractory cases.