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Published on: May 16, 2020
Cardiomyopathy from 1,1-Difluoroethane Inhalation
Suwen Kumar1, Tejaswini Joginpally2, David Kim2
1Department of Medicine, Michigan State University, East Lansing, MI, 48824, USA. suwen.kumar@hc.msu.edu.
Abstract:
Consumer aerosol products can be inhaled for their psychoactive effects, but with attendant adverse health effects including "sudden sniffing death." Cardiomyopathy has rarely been described in association with 1,1-difluoroethane (DFE), a common aerosol propellant. We report a 33-year-old male who developed acute myocardial injury and global hypokinesis along with rhabdomyolysis, acute kidney injury, and fulminant hepatitis after 2 days' nearly continuous huffing. Workup for other causes, including underlying coronary artery disease, was negative. His cardiac function improved over time. The exact mechanism of DFE's effects is uncertain but may include catecholamine-induced cardiomyopathy, coronary vasospasm, or direct cellular toxicity.
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