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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

22.9K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Updated: Mar 29, 2026

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
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High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries

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The "Clickable" Method for Oligonucleotide Immobilization Onto Azide-Functionalized Microarrays.

Tomasz Ratajczak1, Barbara Uszczyńska2,3, Emilia Frydrych-Tomczak4

  • 1Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznan, Poland.

Methods in Molecular Biology (Clifton, N.J.)
|November 29, 2015
PubMed
Summary

Researchers developed a new method for fabricating DNA microarrays using click chemistry. This technique covalently anchors oligonucleotide probes to solid supports, improving gene identification and analysis.

Failed At:

2026-06-19T13:37:26.541486+00:00

Keywords:
Click chemistryDNAFluorescenceHybridizationMicroarraysOligonucleotidesPhosphoramiditeSilanization

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