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Updated: Aug 2, 2026
Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
Published on: November 2, 2011
Parallel Syntheses of Peptides on Teflon-Patterned Paper Arrays (SyntArrays)
Frédérique Deiss1, Yang Yang1, Ratmir Derda2
1Department of Chemistry, Alberta Glycomics Center, University of Alberta, 11227 Saskatchewan Drive, Edmonton, AB, Canada, T6G 2G2.
Abstract:
Screening of peptides to find the ligands that bind to specific targets is an important step in drug discovery. These high-throughput screens require large number of structural variants of peptides to be synthesized and tested. This chapter describes the generation of arrays of peptides on Teflon-patterned sheets of paper. First, the protocol describes the patterning of paper with a Teflon solution to produce arrays with solvophobic barriers that are able to confine organic solvents. Next, we describe the parallel syntheses of 96 peptides on Teflon-patterned arrays using the SPOT synthesis method.
