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Updated: Mar 29, 2026

Author Spotlight: Tackling Challenges in Synthetic Cell Engineering
Published on: April 12, 2024
Manipulation of the ATP pool as a tool for metabolic engineering
Oliver Hädicke1, Steffen Klamt2
1Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, Magdeburg, 39106, Germany haedicke@mpi-magdeburg.mpg.de.
Abstract:
Cofactor engineering has been long identified as a valuable tool for metabolic engineering. Besides interventions targeting the pools of redox cofactors, many studies addressed the adenosine pools of microorganisms. In this mini-review, we discuss interventions that manipulate the availability of ATP with a special focus on ATP wasting strategies. We discuss the importance to fine-tune the ATP yield along a production pathway to balance process performance parameters like product yield and volumetric productivity.
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