Related Experiment Video

Updated: Mar 29, 2026

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
09:48

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

3.7K

[Insulin resistance in children]

Natalia Stąpor1, Iwona Beń-Skowronek1

  • 1Klinika Endokrynologii i Diabetologii Dziecięcej Uniwersytetu Medycznego w Lublinie.

Pediatric Endocrinology, Diabetes, and Metabolism
|November 29, 2015
PubMed

Insights

Insulin resistance, a growing health issue, involves reduced tissue sensitivity to insulin. Factors like lifestyle and genetics contribute to its rise, impacting children

Area of Science:

  • Endocrinology and Metabolism
  • Pediatric Health
  • Public Health

Background:

  • Insulin resistance, characterized by diminished tissue response to insulin, is increasingly prevalent globally.
  • Environmental factors (sedentary lifestyle, excessive calorie intake) and genetic predispositions are key in its pathogenesis.
  • Obesity is a significant consequence and contributor to insulin resistance.

Purpose of the Study:

  • To review current understanding of insulin resistance and glucose tolerance disorders.
  • To outline risk factors, etiological pathways, diagnostic approaches, and health consequences.
  • To highlight the relevance in pediatric populations.

Main Methods:

  • Review of current scientific literature and clinical perspectives.
  • Synthesis of data on risk factors, pathogenesis, and clinical outcomes.
  • Focus on epidemiological trends and physiological states.

Main Results:

  • Insulin resistance is linked to overweight, obesity, and metabolic syndrome.
  • Physiological insulin resistance occurs during puberty.
  • Pathological insulin resistance in children predisposes to abnormal glucose tolerance, type 2 diabetes, hypertension, and polycystic ovary syndrome.

Conclusions:

  • Insulin resistance is a significant health concern with multifactorial causes.
  • Early identification and management are crucial, especially in at-risk pediatric populations.
  • Understanding risk factors and consequences is vital for public health strategies.

Keywords:
insulin receptorinsulin resistance

More Related Videos

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

Published on: January 7, 2018

72.5K
Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.9K

Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
1.2K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
6.0K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.5K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
15.0K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
6.0K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.8K