Related Experiment Video
Updated: Mar 29, 2026

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
Published on: August 13, 2013
Transcriptional and Epigenetic Control of Regulatory T Cell Development
Yohko Kitagawa1, James Badger Wing1, Shimon Sakaguchi1
1Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.
Abstract:
The control of immune responses against self and nonharmful environmental antigens is of critical importance to the immune homeostasis. Regulatory T (Treg) cells are the key players of such immune regulation and their deficiency and dysfunction are associated with various immune disorders, such as autoimmunity and allergy. It is therefore essential to understand the molecular mechanisms that make up Treg cell characteristics; that is, how their unique gene expression profile is regulated at transcriptional and epigenetic levels. In this chapter, we focus on the components of molecular features of Treg cells and discuss how they are introduced during their development.
More Related Videos
11:50Retroviral Transduction of Helper T Cells as a Genetic Approach to Study Mechanisms Controlling their Differentiation and Function
Published on: November 4, 2016
07:17Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
Related Concept Videos
Epigenetic Regulation
Epigenetic Regulation
X-chromosome...
Epigenetic Regulation
Master Transcription Regulators
Regulation of Expression Occurs at Multiple Steps
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps