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GnRH agonist trigger does not always cause luteolysis: a case report.

Shahar Kol1, Tatiana Breyzman1

  • 1Department of Obstetrics and Gynecology, IVF Unit, Rambam Health Care Campus, Haifa, Israel.

Reproductive Biomedicine Online
|December 1, 2015
PubMed
Summary
This summary is machine-generated.

In vitro fertilization (IVF) patients with excessive ovarian response can achieve pregnancy without luteal support after gonadotrophin-releasing hormone agonist triggering. Close monitoring is crucial for managing high hormone levels and preventing ovarian hyperstimulation syndrome.

Keywords:
GnRHa triggerluteal coastingluteal supportluteolysisovarian hyperstimulation syndrome

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Area of Science:

  • Reproductive Endocrinology
  • In Vitro Fertilization (IVF)
  • Ovarian Response Management

Background:

  • Gonadotrophin-releasing hormone agonist (GnRHa) triggering is used in IVF for final oocyte maturation.
  • Excessive ovarian response poses a risk of ovarian hyperstimulation syndrome (OHSS).
  • Standard protocols often include exogenous luteal support.

Observation:

  • A case of an IVF patient with excessive ovarian response undergoing GnRHa triggering is presented.
  • Fourteen oocytes were retrieved, and one embryo was transferred.
  • Despite no exogenous luteal support, the patient exhibited consistently high estradiol and progesterone levels.

Findings:

  • A clinical pregnancy was achieved.
  • The patient did not develop any signs or symptoms of OHSS.
  • Individualized monitoring of hormonal levels was sufficient for managing luteal phase support.

Implications:

  • This case suggests that exogenous luteal support may not be necessary for all IVF patients with excessive ovarian response following GnRHa triggering.
  • Close, individualized patient monitoring is paramount in managing high hormonal profiles post-trigger.
  • This approach could potentially simplify IVF protocols and reduce medication burden.