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Induction of Ocular Surface Inflammation and Collection of Involved Tissues
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Interleukin-17 and its correlation with vascular endothelial growth factor expression in ocular surface pathologies:
Basel Jabarin1, Abraham Solomon1, Radgonde Amer1
1Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem - Israel.
European Journal of Ophthalmology
|December 1, 2015
Summary
Interleukin-17 (IL-17) is elevated in pterygium and inflamed juvenile conjunctival nevus (IJCN). Blocking IL-17 may offer a new treatment strategy for these ocular surface conditions.
Area of Science:
- Ophthalmology
- Immunology
- Cell Biology
Background:
- Ocular surface inflammatory conditions like pterygium and inflamed juvenile conjunctival nevus (IJCN) have complex etiologies.
- Interleukin-17 (IL-17) is a pro-inflammatory cytokine implicated in various inflammatory diseases.
- Understanding the role of specific cytokines in ocular pathologies is crucial for developing targeted therapies.
Purpose of the Study:
- To evaluate the expression of Interleukin-17 (IL-17) in pterygium and inflamed juvenile conjunctival nevus (IJCN).
- To investigate the correlation between IL-17 expression and vascular endothelial growth factor (VEGF) expression in these conditions.
- To explore the potential therapeutic implications of targeting IL-17 in ocular surface inflammation.
Main Methods:
- Immunohistochemical analysis was performed on 50 pterygium and 9 IJCN specimens.
- The expression patterns of IL-17 and VEGF were analyzed.
- Correlation between IL-17 and VEGF expression was statistically assessed.
Main Results:
- IL-17 was significantly expressed in pterygia (84%) and IJCN (100%), with minimal expression in normal conjunctiva.
- VEGF was also highly expressed in pterygia (92%) and IJCN (100%), compared to normal conjunctiva.
- IL-17 was primarily found in epithelial cells and vascular endothelium in pterygia, and in inflammatory infiltrates in IJCN.
Conclusions:
- The study confirms the presence and significant expression of IL-17 in pterygium and IJCN.
- These findings suggest IL-17 plays a role in the pathogenesis of these ocular surface inflammatory diseases.
- Targeting IL-17 could be a potential therapeutic strategy for managing pterygium and IJCN, and preventing pterygium recurrence.
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