Ciprofloxacin for the treatment of osteomyelitis: a review

The authors review the use of ciprofloxacin, a new oral quinolone antibiotic, for the treatment of bone infections. The article discusses the spectrum of activity, pharmacokinetics, and toxicity of the quinolone agents. The authors also provide a detailed discussion of the efficacy of ciprofloxacin for osteomyelitis in animal studies and human trials.