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Updated: Mar 29, 2026
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Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
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Immunological contributions to adipose tissue homeostasis
Joanna R DiSpirito1, Diane Mathis1
1Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Seminars in Immunology
|December 1, 2015
Summary
Adipose tissue
Area of Science:
- Immunology
- Metabolic Science
- Cell Biology
Background:
- Adipose tissue comprises distinct adipocyte types (white, brown, beige) with crucial metabolic roles.
- Adipocyte functions, including lipid storage and insulin response, are modulated by the immune system.
- Obesity and overnutrition induce chronic low-grade adipose tissue inflammation, impacting metabolic health.
Purpose of the Study:
- To review immune system interactions with adipocytes and adipose tissue.
- To examine the consequences of these interactions in the context of chronic overnutrition.
- To discuss diet composition's role in adipose tissue inflammation and gut microbiota disruption.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of immune cell populations (innate and adaptive) in adipose tissue.
- Examination of adipokine secretion and endocrine functions of adipocytes.
Main Results:
- Immune cells can either protect against or worsen adipose tissue inflammation associated with metabolic dysfunction.
- Chronic overnutrition exacerbates adipose tissue inflammation, impairing adipocyte function.
- Diet composition and gut microbiota alterations are implicated in driving pathological adipose tissue inflammation.
Conclusions:
- Immune system modulation is critical for adipose tissue homeostasis and metabolic health.
- Understanding diet-microbiota-adipose tissue axis is essential for addressing obesity-related inflammation.
- Targeting immune-adipose interactions may offer therapeutic strategies for metabolic diseases.
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