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[Recent advances in bladder urothelial carcinogenesis]

Géraldine Pignot1, Constance le Goux2, Ivan Bieche2

  • 1Institut Paoli-Calmettes, service de chirurgie urologique, 13009 Marseille, France.

Bulletin Du Cancer
|December 1, 2015
PubMed

Insights

Bladder cancer prognosis is poor, but molecular insights reveal subtypes based on genetic alterations like FGFR3 and TP53. This enables personalized medicine and targeted therapies for better treatment outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Context:

  • Bladder cancer is a significant cause of cancer mortality in France.
  • Prognosis for muscle-invasive bladder tumors is poor due to limited effective treatments.
  • Recent molecular biology and genome-wide studies have advanced understanding of bladder carcinogenesis.

Purpose:

  • To review genetic and epigenetic alterations in bladder cancer.
  • To explore the role of these alterations as theranostic markers.
  • To discuss new targeted therapies within personalized medicine.

Summary:

  • Key molecular alterations in bladder cancer include FGFR3, TP53, and HER2.
  • These alterations allow for the classification of tumors into three distinct molecular subgroups.
  • The review covers genetic and epigenetic changes, theranostic potential, and personalized therapeutic strategies.

Impact:

  • Advances in understanding bladder cancer molecular profiles.
  • Potential for improved theranostic markers in clinical oncology.
  • Development of new targeted therapies for personalized bladder cancer treatment.
Keywords:
Bladder cancerCarcinogenesisCarcinogenèseMarqueurs moléculairesMolecular markersTargeted therapiesThérapies cibléesTumeur de vessie

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