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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.9K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.9K
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.5K
6.5K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.6K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.6K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

17.3K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
17.3K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

18.3K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
18.3K
T Cell Types and Functions01:24

T Cell Types and Functions

3.3K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.3K

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Related Experiment Video

Updated: Mar 29, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

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Notch in T Cell Differentiation: All Things Considered.

Derk Amsen1, Christina Helbig1, Ronald A Backer2

  • 1Department of Hematopoiesis, Sanquin and Landsteiner Laboratory at the CLB, Plesmanlaan125, 1066CX, Amsterdam, the Netherlands.

Trends in Immunology
|December 1, 2015
PubMed
Summary
This summary is machine-generated.

The Notch signaling pathway is crucial for T cell differentiation into effector cells, essential for immunity and memory. Understanding its diverse roles offers therapeutic potential for immune disorders.

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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

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Mouse Na&#239;ve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Naïve T cell differentiation into effector cells is vital for pathogen defense and immune memory.
  • The Notch signaling pathway plays a significant role in T cell differentiation into various effector subsets.
  • Preclinical studies suggest Notch pathway manipulation could treat immune pathologies.

Purpose of the Study:

  • To review the mechanisms by which Notch signaling controls T cell differentiation into diverse effector subsets.
  • To explore the therapeutic potential of targeting the Notch pathway in immune-related diseases.
  • To identify unifying principles and context-specific differences in Notch-mediated T cell fate decisions.

Main Methods:

  • Literature review of preclinical studies and existing research on Notch signaling in T cell differentiation.
  • Analysis of findings related to Notch pathway's role in various T cell effector subsets.
  • Identification of potential therapeutic intervention points based on Notch pathway regulation.

Main Results:

  • Notch signaling is a key regulator controlling T cell differentiation into all known effector lineages.
  • The pathway exhibits both unifying principles and cell type/context-specific variations in directing T cell fate.
  • Understanding these mechanisms highlights opportunities for therapeutic modulation.

Conclusions:

  • The Notch pathway is a central orchestrator of T cell effector differentiation, impacting immunity and memory.
  • Targeting Notch signaling presents a promising strategy for managing immune pathologies.
  • Further research into Notch-mediated T cell fate decisions can guide therapeutic interventions.