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Updated: Mar 29, 2026

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
Published on: October 10, 2012
Potential of neuropeptide Y for preventing or treating post-traumatic stress disorder
Esther L Sabban1, Lishay G Alaluf1, Lidia I Serova1
1Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, United States.
Abstract:
There is extensive evidence that NPY in the brain can modulate the responses to stress and play a critical role in resistance to, or recovery from, harmful effects of stress. Development of PTSD and comorbid depression following exposure to traumatic stress are associated with low NPY. This review discusses putative mechanisms for NPY's anti-stress actions. Recent preclinical data indicating potential for intranasal delivery of NPY to brain as a promising non-invasive strategy to prevent a variety of neuroendocrine, molecular and behavioral impairments in PTSD model are summarized.
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