Related Experiment Video

Updated: Jan 28, 2026

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

891

Low MiR-149 expression is associated with unfavorable prognosis and enhanced Akt/mTOR signaling in glioma

Liang Xue1, Yi Wang1, Shuyuan Yue1

  • 1Department of Neurosurgery, Tianjin Medical University General Hospital Tianjin 300052, P. R. China.

International Journal of Clinical and Experimental Pathology
|December 1, 2015
PubMed

Insights

Low miR-149 expression in glioma tumors is linked to poorer patient survival. This microRNA (miRNA) may serve as a prognostic biomarker for glioma, potentially impacting treatment strategies.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are crucial regulators in glioma development.
  • Previous research indicated miR-149 has anti-tumor properties in glioma cell lines.

Purpose of the Study:

  • To determine the association between miR-149 expression and glioma patient prognosis.
  • To investigate the clinical significance of miR-149 in glioma.

Main Methods:

  • Analysis of miR-149 expression in tumor and normal tissues from 163 glioma patients.
  • Kaplan-Meier survival analysis and multivariate Cox regression were employed.
  • Investigation of Akt/mTOR signaling pathway activity in relation to miR-149 levels.

Main Results:

  • miR-149 expression was significantly lower in glioma tissues compared to normal tissues.
  • Low miR-149 expression correlated with shorter survival duration (logrank test, P<0.001).
  • Patients with low miR-149 had a 1.825-fold increased risk of death (HR=1.825, P=0.039), with hyperactive Akt/mTOR signaling observed.

Conclusions:

  • Glioma miR-149 expression is significantly associated with patient prognosis.
  • miR-149 may serve as a potential prognostic biomarker for glioma.
  • Aberrant Akt/mTOR signaling is linked to reduced miR-149 expression in glioma.
Keywords:
AktGliomamTORmiR-149prognosis

More Related Videos

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

8.3K
Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells09:58

Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells

Published on: May 2, 2017

8.0K

Related Concept Videos

PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
5.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.7K
What is Cell Signaling?02:03

What is Cell Signaling?

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
130.3K
Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
40.6K
Self-Evaluation: Self-Enhancement and Self-Verification03:00

Self-Evaluation: Self-Enhancement and Self-Verification

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.8K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
53.4K