Relationship between serologic response and clinical symptoms in children with enterovirus 71-infected

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Jun Shen1, Chao Zhao2, Ping Cao1

  • 1Department of Infectious Disease, Children's Hospital of Fudan University Shanghai, China.

International Journal of Clinical and Experimental Pathology
|December 1, 2015
PubMed

Insights

Enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) are key causes of hand-foot-mouth disease (HFMD) in children. EV71 IgM antibody levels correlate with fever and rash duration in HFMD patients.

Area of Science:

  • Virology
  • Pediatrics
  • Infectious Diseases

Background:

  • Hand-foot-mouth disease (HFMD) is a common viral illness in children.
  • Enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) are the primary causative agents of HFMD outbreaks.
  • Understanding the relationship between clinical symptoms and viral markers is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the correlation between clinical symptoms (rash, fever) and serum antibody responses to EV71 infection in hospitalized children with HFMD.
  • To identify the prevalent EV71 and CA16 strains during a specific HFMD epidemic period.

Main Methods:

  • Retrospective analysis of 547 children hospitalized with HFMD from May to July 2014.
  • Detection of EV71 and CA16 RNA in fecal, serum, and cerebrospinal fluid using quantitative real-time RT-PCR.
  • Measurement of EV71-IgM antibodies in serum via immune colloidal gold assays.

Main Results:

  • EV71 and CA16 were identified as the major pathogens, with a combined fecal positive rate of 72.58%.
  • A high prevalence of EV71-IgM antibodies was observed in 75.18% of serum samples.
  • The duration of fever and rash showed a significant correlation with positive rates of serum EV71-IgM and combined EV71 markers.

Conclusions:

  • EV71 and CA16 were the predominant pathogens causing HFMD in Shanghai during the study period.
  • Serum EV71-IgM positivity is closely linked to the duration of fever and rash in children with EV71 infection.
  • These findings aid in understanding EV71 pathogenesis and clinical presentation in pediatric HFMD.

Keywords:
Hand-foot-mouth diseasechildrenenterovirus 71feverrashserum antibody

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