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Genetic association between CD44 polymorphisms and chronic hepatitis B virus infection in a Chinese Han population

Fan Li1, Qing Shao1, Dong Ji1

  • 1Liver Fibrosis Diagnosis and Treatment Center, 302 Military Hospital of China Beijing 100039, China.

International Journal of Clinical and Experimental Pathology
|December 1, 2015
PubMed

Insights

CD44 gene variations are linked to chronic hepatitis B virus (HBV) infection in the Chinese Han population. These CD44 polymorphisms act as risk factors and interact synergistically, increasing susceptibility to HBV infection.

Area of Science:

  • Genetics
  • Immunology
  • Hepatology

Background:

  • Chronic hepatitis B virus (HBV) infection remains a significant global health concern.
  • Understanding the genetic factors influencing HBV susceptibility is crucial for developing effective prevention and treatment strategies.
  • CD44, a cell surface glycoprotein, plays roles in immune cell trafficking and inflammation, potentially influencing HBV pathogenesis.

Purpose of the Study:

  • To investigate the association between CD44 gene polymorphisms (rs187115 and rs13347) and chronic HBV infection in the Chinese Han population.
  • To analyze the potential interaction between these CD44 polymorphisms in the context of HBV infection.

Main Methods:

  • Genotyping of CD44 polymorphisms (rs187115, rs13347) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  • Case-control study involving 108 HBV-infected individuals and 130 healthy controls.
  • Statistical analysis including Hardy-Weinberg equilibrium, chi-squared test, odds ratios (OR) with 95% confidence intervals (CI), and crossover analysis for interaction.

Main Results:

  • The GG genotype and G allele of CD44 rs187115 were significantly more frequent in HBV-infected cases compared to controls (P=0.02, P=0.04).
  • Carriers of mutant genotypes (CT, TT) and the combined CT+TT genotype of CD44 rs13347 exhibited a significantly higher risk of HBV infection (OR=1.99-3.56).
  • The T allele of rs13347 also increased the risk of HBV infection (OR=1.98). A positive interaction was observed between the two CD44 polymorphisms.

Conclusions:

  • CD44 polymorphisms (rs187115 and rs13347) are associated with chronic HBV infection in the Chinese Han population.
  • These CD44 polymorphisms function as risk factors for HBV infection.
  • A synergistic interaction between the studied CD44 polymorphisms contributes to increased susceptibility to chronic HBV infection.
Abstract

Keywords:
CD44chronic hepatitis B virus infectionpolymorphism

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