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A case report on intermediate-grade malignant meningeal melanocytoma with elevated cell proliferation index
Jian Sun1, Chengjun Wang1, Qingming Shu2
1Department of Neurosurgery, Chinese People's Armed Police Force General Hospital Beijing 100039, China.
Abstract:
Meningeal melanocytoma is a kind of extremely rare pigmented tumor of the central nervous system, which often occurs in the groove around the base of the brain and spinal pia mater. Age of onset is 40 to 50 years old, mostly presenting a benign course of disease and the prognosis is good. Case reports of partial invasion or metastasis from lesions are even rarer. This report described a case of 56-year-old meningeal melanoma patient with partial skull and muscle invasion at the lantooccipital transition zone. Intraoperative histological examination showed moderate malignancy and Ki-67 index was 10%.
Insights
Meningeal melanocytoma, a rare central nervous system tumor, can exhibit rare invasion. This case highlights a 56-year-old patient with skull and muscle invasion, indicating potential for advanced disease.
Area of Science:
- Neuro-oncology
- Pathology
Background:
- Meningeal melanocytoma is an exceptionally rare central nervous system tumor, typically found at the brain's base or spinal pia mater.
- While generally benign with a good prognosis, rare instances of invasion or metastasis occur.
Observation:
- This report details a 56-year-old patient diagnosed with meningeal melanoma.
- The tumor presented with partial invasion into the skull and adjacent muscles at the lantooccipital transition zone.
Findings:
- Intraoperative histological examination revealed a moderately malignant tumor.
- The Ki-67 proliferation index was determined to be 10%.
Implications:
- This case underscores the importance of considering invasive potential even in rare meningeal melanocytomas.
- Further research into the factors influencing invasion and metastasis in these tumors is warranted.
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