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Related Experiment Video

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Development of a Virtual Reality Assessment of Everyday Living Skills
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Assessment of Age-Related Differences in Functional Capacity Using the Virtual Reality Functional Capacity Assessment

A S Atkins1, I Stroescu1, N B Spagnola1

  • 1NeuroCog Trials, Inc.

The Journal of Prevention of Alzheimer'S Disease
|December 1, 2015
PubMed
Summary
This summary is machine-generated.

The Virtual Reality Functional Capacity Assessment Tool (VRFCAT) shows promise for measuring functional changes in healthy aging and early Alzheimer's disease (AD) detection. It demonstrates good reliability and correlates with cognitive performance, making it suitable for clinical trials.

Keywords:
Functional capacityagingfunctional outcomemeaningful changeprodromal AD

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Area of Science:

  • Neuroscience
  • Gerontology
  • Human-Computer Interaction

Background:

  • Clinical trials for preclinical Alzheimer's disease (AD) need sensitive functional capacity measures.
  • The Virtual Reality Functional Capacity Assessment Tool (VRFCAT) was developed for this purpose.

Purpose of the Study:

  • Evaluate VRFCAT's test-retest reliability and association with cognitive performance.
  • Assess VRFCAT's suitability for healthy aging and preclinical mild cognitive impairment/AD (MCI/AD) trials.

Main Methods:

  • VRFCAT assesses shopping-related instrumental activities in a virtual reality environment.
  • Compared VRFCAT with the UPSA-2-VIM (a traditional assessment).
  • Examined performance in healthy young and older adults.

Main Results:

  • VRFCAT showed significant age-related performance differences.
  • VRFCAT performance strongly correlated with cognitive function.
  • VRFCAT Total Time demonstrated good test-retest reliability (ICC=.80 young, .64 older) with minimal practice effects.

Conclusions:

  • VRFCAT is a reliable tool for assessing functional capacity in healthy aging and preclinical AD/MCI.
  • Preliminary findings support VRFCAT's use in primary prevention and early intervention trials.