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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
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Ototoxicity (cochleotoxicity) classifications: A review.

Gemma Crundwell1, Phil Gomersall1,2, David M Baguley1,2

  • 1a Audiology Department, Cambridge University Hospitals NHS Foundation Trust , Cambridge , UK.

International Journal of Audiology
|December 1, 2015
PubMed
Summary
This summary is machine-generated.

This review examines drug-induced hearing loss classification systems. Current methods often lack sensitivity and fail to capture clinically significant changes, necessitating improved ototoxicity monitoring tools.

Keywords:
Ototoxicitycochleotoxicityhearing

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Area of Science:

  • Ototoxicology
  • Audiology
  • Pharmacology

Background:

  • Drug-induced ototoxicity, particularly cochleotoxicity, is a significant clinical concern.
  • Existing classification schemes for iatrogenic hearing loss often rely on pure-tone audiometry.
  • These systems aim to aid non-specialists in identifying and monitoring drug-related hearing impairment.

Purpose of the Study:

  • To identify and review primary classification systems for cochleotoxicity monitoring.
  • To increase awareness of the strengths and limitations of current ototoxicity assessment tools.
  • To suggest improvements for future classification systems in evaluating drug-induced hearing loss.

Main Methods:

  • A literature review was conducted.
  • A systematic search of PubMed using the term "ototox*" identified 4878 articles.
  • Thirteen key classification systems for cochleotoxicity were identified.

Main Results:

  • Cochleotoxicity classification systems were categorized based on their focus: changes from baseline audiogram or functional impact of hearing loss.
  • The review identified 13 primary classification systems used in clinical practice.

Conclusions:

  • Common weaknesses in current grading scales include poor sensitivity to minor hearing threshold changes.
  • Lack of high-frequency audiometry (>8 kHz) assessment is a limitation.
  • Current systems often fail to indicate clinically significant changes impacting communication and quality of life.