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Study on lipid and glucose metabolism in patients with vasospastic angina
H Yoshida1, K Murakami, G Mimura
1Second Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Insights
This study found that lipid metabolism, specifically higher total cholesterol and atherogenic index, is linked to coronary artery disease (CAD). Vasospastic angina (VSA) patients showed elevated apolipoprotein A-I and A-II levels compared to CAD patients.
Area of Science:
- Cardiology
- Metabolic Research
- Clinical Investigation
Background:
- Vasospastic angina (VSA) is a form of ischemic heart disease.
- Understanding the role of lipid and glucose metabolism in VSA is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate the association between lipid and glucose metabolism and vasospastic angina.
- To compare metabolic profiles of patients with VSA, coronary artery disease (CAD), and controls.
Main Methods:
- A comparative study involving 93 patients categorized into control (30), CAD (47), and VSA (16) groups.
- Analysis of age, total cholesterol, triglycerides, HDL-cholesterol, atherogenic index, apolipoproteins (A-I, A-II), and diabetes mellitus prevalence.
Main Results:
- Coronary artery disease (CAD) group showed significantly higher total cholesterol and atherogenic index compared to control and VSA groups.
- Vasospastic angina (VSA) group exhibited significantly higher apolipoprotein A-I and A-II levels than both control and CAD groups.
- No significant differences in triglyceride levels or diabetes mellitus prevalence were observed among the groups.
Conclusions:
- Lipid metabolism, particularly elevated total cholesterol and atherogenic index, is strongly associated with coronary artery disease.
- Distinct apolipoprotein profiles (A-I and A-II) characterize vasospastic angina, suggesting a unique metabolic pathway.
- Further research into these metabolic differences may lead to improved diagnostic markers and therapeutic strategies for VSA.
Abstract:
The primary purpose of the present study was to evaluate the role of lipid and glucose metabolism in vasospastic angina. A group of 93 patients in whom the presence of ischemic heart disease was suggested, were classified into the control (C) group, consisting of 30 patients; the coronary artery disease (CAD) group, consisting of 47 patients; and the vasospastic angina (VSA) group, consisting of 16 patients. Among these three groups, age, total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C), atherogenic index (AI), apolipoproteins and the prevalence of diabetes mellitus were compared. No age difference was seen among the three groups. The TC was the highest in the CAD group, followed by the VSA and C groups. A significant difference in TC was noted between the C and CAD groups and the C and VSA groups. TG levels were higher in the CAD group than in the C and VSA groups, without a significant difference among the three groups. The AI was significantly higher in the CAD group than in the C and VSA groups. No significant difference was noted in the prevalence of diabetes mellitus among the three groups. Apolipoprotein A-I (apo A-I) levels were higher in the VSA group than in the C and CAD groups, and the difference between the VSA and CAD groups was significant. Apolipoprotein A-II (apo A-II) levels were significantly higher in the VSA group than in the C and CAD groups.(ABSTRACT TRUNCATED AT 250 WORDS)