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Related Concept Videos

Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

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Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
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2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

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Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
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NMR Spectroscopy: Spin–Spin Coupling01:08

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The spin state of an NMR-active nucleus can have a slight effect on its immediate electronic environment. This effect propagates through the intervening bonds and affects the electronic environments of NMR-active nuclei up to three bonds away; occasionally, even farther. This phenomenon is called spin–spin coupling or J-coupling. Coupling interactions are mutual and result in small changes in the absorption frequencies of both nuclei involved. While nuclei of the same element are involved...
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2D NMR: Overview of Heteronuclear Correlation Techniques01:18

2D NMR: Overview of Heteronuclear Correlation Techniques

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Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other...
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¹³C NMR: ¹H–¹³C Decoupling01:04

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The probability of having two carbon-13 atoms next to each other is negligible because of the low natural abundance of carbon-13. Consequently, peak splitting due to carbon-carbon spin-spin coupling is not observed in spectra. However, protons up to three sigma bonds away split the carbon signal according to the n+1 rule, resulting in complicated spectra.
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
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¹H NMR: Long-Range Coupling01:27

¹H NMR: Long-Range Coupling

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The coupling interactions of nuclei across four or more bonds are usually weak, with J values less than 1 Hz. While these are usually not observed in spectra, the presence of multiple bonds along the coupling pathway can result in observable long-range coupling.
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene...
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Using magnetic coupling to implement (1)H, (19)F, (13)C experiments in routine high resolution NMR probes.

Paul Bowyer1, Jim Finnigan2, Brian Marsden3

  • 1Agilent Technologies, Inc., 5301 Stevens Creek Blvd., Santa Clara, CA 95501, United States; Magritek, Inc., 6440 Lusk Blvd., Suite D108, San Diego, CA 92121, United States.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|December 1, 2015
PubMed
Summary

This study introduces magnetic coupling circuitry for nuclear magnetic resonance (NMR) probes, enabling on-demand experiments with selective nuclear observation and decoupling. This innovation preserves probe performance, benefiting fluorine-19 (19F) NMR applications.

Keywords:
(1)H, (19)F, (13)C(1)H–(19)FDouble resonance probe

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Area of Science:

  • Chemistry
  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Materials Science

Background:

  • Routine nuclear magnetic resonance (NMR) probes often require specialized setups for observing specific nuclei while decoupling others.
  • Capacitive coupling methods for NMR circuitry can sometimes impact probe performance.
  • Fluorine-19 (19F) NMR is a crucial technique in various chemical analyses.

Purpose of the Study:

  • To design and implement novel magnetic coupling circuitry for NMR probes.
  • To enable on-demand experiments with selective observation and decoupling of hydrogen-1 (1H), fluorine-19 (19F), and carbon-13 (13C) nuclei.
  • To evaluate the impact of this magnetic coupling circuitry on routine NMR probe performance compared to capacitive coupling.

Main Methods:

  • Design of a magnetic coupling circuitry for (1)H, (19)F, and (13)C nuclei.
  • Integration of the circuitry into standard NMR probes.
  • Comparative performance analysis against capacitive coupling methods.
  • On-demand experimental capability with selective nuclear observation and decoupling.

Main Results:

  • The magnetic coupling circuitry successfully enabled on-demand experiments with selective observation and decoupling of (1)H, (19)F, and (13)C nuclei.
  • Implementation in routine NMR probes showed no negative impact on probe performance when compared to capacitive coupling.
  • The magnetic coupling approach maintained the integrity and performance of standard NMR probes.

Conclusions:

  • Magnetic coupling circuitry offers a non-disruptive method for enhancing NMR probe functionality.
  • This technology is particularly advantageous for chemists frequently performing (19)F NMR experiments.
  • The design facilitates versatile NMR experiments without compromising existing hardware performance.