Related Experiment Video
Updated: Mar 29, 2026
06:14
Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
Published on: January 7, 2019
7.4K
Bicomponent electrospun scaffolds to design extracellular matrix tissue analogs
Vincenzo Guarino1, Valentina Cirillo1, Luigi Ambrosio1
1a Institute for Polymers, Composites and Biomaterials, Department of Chemical Sciences & Materials Technology , National Research Council of Italy , 80125 Naples , Italy.
Expert Review of Medical Devices
|December 1, 2015
Summary
Bicomponent fibers mimic natural extracellular matrices for tissue repair. These advanced fibers offer tunable properties and controlled biomolecule release, enhancing cell activity for regenerative medicine applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Bicomponent fibers offer advantages over monocomponent fibers for bio-inspired systems.
- Their unique structure allows self-adaptation to physiological conditions via morphological, chemical, and physical signals.
- Tunable organization of hydrophobic/hydrophilic phases (blending, core/shell, interweaving) impacts biological activity, fluid sorption, and molecular transport.
Purpose of the Study:
- To provide an overview of bicomponent fiber applications in tissue repair and regenerative medicine.
- To highlight their role as extracellular matrix analogs with cell-instructive functions.
- To discuss their potential in the hierarchical organization of living tissues.
Main Methods:
- Review of current approaches utilizing bicomponent fibers.
- Discussion of processing modes (blending, core/shell, interweaving) for phase organization.
- Exploration of methods for grafting cell-adhesive proteins and peptide sequences.
- Analysis of controlled release of biomolecules (morphogens, growth factors) via spacers or hydrogels.
Main Results:
- Bicomponent fibers can be engineered with tailored properties for specific biological applications.
- Surface modification enables controlled cell adhesion and activity.
- Sustained release of biomolecules from fibers can direct cellular behavior in vitro.
- These fibers serve as advanced scaffolds for tissue regeneration.
Conclusions:
- Bicomponent fibers represent a versatile platform for creating bio-inspired systems.
- They offer significant potential as extracellular matrix analogs for tissue engineering.
- Their ability to provide cell-instructive cues facilitates the hierarchical organization of living tissues.
