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[Pathogen Characteristics of Catheter-related Bloodstream Infection]
Insights
Catheter-related bloodstream infections (CRBSI) are often caused by Gram-negative bacteria, with high resistance to common antibiotics. Strengthening prevention and tailoring treatment based on pathogen susceptibility is crucial.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Hospital Epidemiology
Background:
- Catheter-related bloodstream infections (CRBSI) pose a significant threat in healthcare settings.
- Understanding the specific pathogens and their antimicrobial resistance patterns is vital for effective management.
Purpose of the Study:
- To characterize the pathogens responsible for CRBSI.
- To analyze the antimicrobial susceptibility profiles of isolated pathogens.
Main Methods:
- Retrospective analysis of clinical data from CRBSI patients at West China Hospital (2011-2014).
- Inclusion of pathogen culture and drug susceptibility testing results.
Main Results:
- Eighty-four pathogen strains were isolated from 77 patients, with Gram-negative bacteria (48.8%) being predominant.
- Enterobacteriaceae showed high resistance to ceftriaxone (65.5%), while Staphylococcus spp. exhibited high resistance to clindamycin (81.3%).
- Candida spp. showed no resistance to amphotericin and 5-flucytosine.
Conclusions:
- Enhanced prevention and control strategies for Gram-negative bacilli causing CRBSI are necessary.
- Antimicrobial therapy for CRBSI should be guided by in vitro drug susceptibility data.
Objective:
To determine thepathogen characteristics of catheter-related bloodstream infection (CRBSI).
Methods:
The clinical data of patients with CRBSI who were admitted in West China Hospital, Sichuan University during January 1, 2011 and October 15, 2014 were retrieved, along with findings of pathogen culture and drug susceptibility tests.
Results:
Eighty-four strains of pathogens were isolated from 77 patients, which included 41 strains (48. 8%) of Gram-negative bacteria, 23 strains (27. 4%) of Gram-positive bacteria, and 20 strains of fungus (23. 8%). Enterobacteriaceae was predominant (29/41, 70.7%) in the Gram-negative bacteria,followed by non-fermenting bacteria (12/41, 29. 3%). Staphylococcus spp. was the main (16/23, 69. 6%) species of Gram- positive bacteria. Candida albicans led to 35. 0% (7/20) fungi infection. Resistance of Enterobacteriaceae to ceftriaxone was high (65. 5%, the highest), compared with its resistance to imipenem (3. 4%, the lowest). The non-fermentative bacterial had complete (100%) resistance to nitrofurantoin, and 16. 7% resistance (the lowest)to levofloxacin. Staphylococcus spp. had 81. 3% resistance (highest) to clindamycin, and zero resistance to vancomycin andlinezolid. Resistance to amphotericin and 5-flucytosine was not found in Candida spp. isolates.
Conclusion:
Prevention and control of CRBSI caused by Gram negative bacilli should be strengthened in the hospital. Clinical treatments should be guided by the in vitro drug susceptibility of pathogens.
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