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[Biomarker for evaluation and management of hypertensives]

Tatsuo Shimosawa

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |December 2, 2015
    PubMed

    Insights

    Hypertension biomarkers aid diagnosis and risk assessment. Future research focuses on proteomic and metabolomic analyses for improved salt-sensitivity and organ damage detection.

    Area of Science:

    • Cardiovascular Medicine
    • Biomarker Discovery
    • Hypertension Research

    Context:

    • Current hypertension guidelines recommend established cardiovascular risk and organ damage markers.
    • Physical examination is crucial, alongside consideration of marker sensitivity, specificity, and likelihood.
    • Existing markers include CAVI, AI, and FMD, with ongoing evidence accumulation.

    Purpose:

    • To review the application of biomarkers in hypertension diagnosis, risk evaluation, and therapeutic efficiency.
    • To highlight the potential of novel biomarkers for specific conditions like salt-sensitivity and tubular damage.

    Summary:

    • Biomarkers are essential for hypertension management, guiding diagnosis, risk stratification, and treatment response.
    • Established markers like CAVI, AI, and FMD are used, but novel approaches are emerging.
    • Proteomics, metabolomics, and microRNAs show promise for future diagnostic advancements.

    Impact:

    • Enhanced diagnostic accuracy for hypertension and related complications.
    • Improved risk stratification enabling personalized therapeutic strategies.
    • Development of novel biomarkers for early detection of organ damage and salt-sensitivity.

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