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[Chronotherapy of hypertension]
Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 2, 2015
Summary
Blunted night-time blood pressure decline increases cardiovascular risk in hypertension. Chronotherapy optimizes antihypertensive drug dosing for better patient outcomes and reduced toxicity.
Area of Science:
- Pharmacology
- Cardiology
- Chronobiology
Context:
- Hypertension management requires controlling blood pressure (BP) during both day and night.
- A blunted nocturnal BP decline is linked to increased cardiovascular event risk.
- Drug efficacy and toxicity can vary based on administration timing.
Purpose:
- To discuss the principles of chronotherapy in managing hypertension.
- To explore the optimal dosing strategies for various antihypertensive drug classes.
Summary:
- Chronotherapy, applying chronopharmacology and chronotoxicology, aims to enhance drug effectiveness and tolerance.
- This approach considers the body's circadian rhythms for drug administration.
- The article reviews chronotherapy for angiotensin-converting enzyme inhibitors, calcium channel blockers, alpha-1 blockers, diuretics, and angiotensin II receptor blockers.
Impact:
- Improved patient prognosis through optimized blood pressure control.
- Enhanced therapeutic efficacy of antihypertensive medications.
- Reduced adverse effects and improved drug tolerance by aligning dosing with circadian rhythms.
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